ABSTRACT
Risk assessment for fast growing burden of cardiovascular diseases is very important and difficult. As a response to this challenge, in particular, genetic risk factors which potentially modify risk, we conducted a survey of primary data registry of Shiraz Heart Study on integration and application of family history data in prevention of cardiovascular disorders. This study is a longitudinal cohort project to be extended from subpopulations of different job groups to the community. Parental family history of MI, diabetes mellitus [DM], hyperlipidemia [HPL], hypertension [HTN] was reported more frequently among females than males. Histories of MI, DM, HPL, and HTN in both parents were respectively positive in 2.6%, 2%, 4.6%, and 7.9% of the participants. Odd ratios [OR] for risk of MI from family history of MI were 2.7; risk of DM from family history of DM 4.5; risk of HPL from family history of HPL 2.04; and risk of HTN from family history HTN 4.7. Also, family history of MI modifies risk of HPL [OR=1.7, P<0.0001]; and family history of DM modifies risk of HPL [OR=2.04, P<0.0001]. Our primary result shows potent application of family history data in risk assessment of cardiovascular outcome. In particular, HTN appears as a silent and leading risk modifier. In regard to the course of continuing Shiraz Heart Study integration of family history of risk factors crucial in public health we suggest to adopt a network of electronic health records from the [Health House] to the [Heart House]
ABSTRACT
Randomized controlled studies over the last 4 decades demonstrated that controlling blood pressure could reduce the risks of cardiovascular disease. The relationship between diet ingredient [particularly the salt] and blood pressure has been well established and since bread is the main element in population diet, especially in our country, the determination of sodium content of bread is of high priority and warrants further investigation. A total of 204 bakeries were selected for this study and the amount of salt in different bread was measured once during spring and summer, using the method of Iran's Organization for Standards and Industrial Investigation. The study was performed on 6 different kinds of bread baked in different districts of Shiraz city. This study demonstrated that 17.9% of bread's salt level in Shiraz exceeds the standard level and the remaining 82.1% is within the standard range. Mean percentage of bread's salt was reported as 1.31 gram%. Compared to the previous reports, the results of present study fortunately showed a reduction of salt in bread during the last two decades. However, 17.9% of bread's salt is yet more than the standard level
ABSTRACT
Coronary artery diseases [CAD] are the leading cause of mortality, morbidity and disability with high health care cost in any countries including Iran. The prevalence of all CAD risk factors including hypertension, diabetes, lipid profile abnormalities and obesity is rising in the population of Iran. Knowing the population at risk would lead to proper education to decrease these risk factors and ultimately would reduce CAD. This descriptive cross- sectional study was conducted in February to December 2009 and comprised a total of 3115 Shiraz educational staff, aged 21- 73 years. Questionnaires were applied to collect information including; demographic data, physical activity, history of CAD, hypertension, dyslipidemia, and smoking. In addition, waist circumference, height, weight, body mass index [BMI], and hip circumference [HC] were measured and serum biochemistry profiles were determined on venous blood samples. Such data helped identify the prevalence of diabetes, hypercholesterolemia, hypertriglyceridemia, hypertension, overweight and obesity, central obesity, and smoking. The mean age of 3115 participant was 42.7 and 41.5 years for men and women respectively. The prevalence of pre-diabetes, diabetes hypertension, hypercholesterolemia and hypertriglyceridemia were%10.2,%4,%18.2,%38.30 and%33.2 respectively. Diabetes, hypertension and dyslipidemia were more prevalent among males and older subjects. The prevalence of central obesity was%75.05 [IDF criteria] and%40.64 [ATP- III criteria]. The frequency of obesity, current smoking, ex-smoking and passive smoking were%12.1,%5.85,%1.52 ,%7.9 respectively which were below the reported prevalence in Iran in previous studies, but physical inactivity was%73.3 which is very high in this study group. Although CAD risk factors seem to be very common in the study population, clinical and paraclinical data indicated that teachers residing in Shiraz have a lower rate of CAD risk factors in comparison with previous studies done in general population of Iran. This may be related to high level of education, awareness and better lifestyle in the study group. But still further educating in regard to lifestyle modifications as well as dietary surveillance is needed in general population including those dealing with educating children and on a larger scale, the community as a whole